It looks like your browser is out-of-date! For the best user experience, please upgrade to a more modern browser like Chrome or Edge.

Skip to Main Content
Visitor Guidelines | Directrices de visitas

We are taking thoughtful steps to ensure our spaces remain safe for patients, parents and caregivers. View safety measures, mask policy and visiting guidelines.

Estamos adoptando medidas reflexivas para garantizar que nuestros espacios sigan siendo seguros para los pacientes, los padres y los cuidadores. Vea las medidas de seguridad, la política de uso de mascarillas y las directrices de visitas.

Mobile sized logo
  • 317.944.5000
    • Schedule an Appointment
    • Refer a Patient
    • Plan My Visit
    • Pay a Bill
    • Make a Donation
    • Volunteer
    • Find a Career
    • Health Information
    • Find a Doctor
    • Departments & Programs
    • Support Services
    • Contact & Locations
    • Refer a Patient
    • My IU Health Patient Portal
Riley Children's Health
  • 317.944.5000
  • My IU Health Patient Portal
    • Schedule an Appointment
    • Refer a Patient
    • Plan My Visit
    • Pay a Bill
    • Make a Donation
    • Volunteer
    • Find a Career
Book Appointment Online with select physicians.
Request Appointment Online to schedule with one of our coordinators.
1.888.IUHEALTH for
Same-Day Primary Care Appointments.
If you are experiencing a medical emergency, please call 9-1-1.
    • Schedule an Appointment
    • Refer a Patient
    • Plan My Visit
    • Pay a Bill
    • Make a Donation
    • Volunteer
    • Find a Career
  • Health Information
  • Find a Doctor
  • Departments & Programs
  • Support Services
  • Contact & Locations
  • My IU Health Patient Portal
  • General Information
    317.944.5000
  • Health Information
  • Find a Doctor
  • Departments & Programs
  • Support Services
  • Contact & Locations
Riley Children's Health

Osteosarcoma

Osteosarcoma
  • Find a Doctor
  • Request An Appointment
  • On This Page:
  • Overview
  • Tests & Diagnosis
  • Treatments
  • Key Points To Remember
  • Support Services & Resources
  • Research & Clinical Trials
  • Locations
  • Departments Treating This Condition
  • Related Stories
Go back to the top of the page

Osteosarcoma is the most common bone cancer, or tumor, in children and adolescents and the third most common childhood cancer. In the U.S., 400 new cases of osteosarcoma are diagnosed each year. Most patients are diagnosed with osteosarcoma in adolescence between the ages of 10 and 19 years old. Children below 5 years of age are rarely diagnosed with this type of cancer. Osteosarcoma occurs more frequently in males than in females.

What is osteosarcoma?

What is osteosarcoma?

Although tumors can occur in any bone, they most frequently occur in the long bones of the arms and legs near the ends where tissue grows, called growth plates. The most common sites are the femur (thighbone) above the knee, the fibula (shinbone) below the knee and the humerus (upper arm bone).

Other significant locations are the skull, jaw and hip bones. By the time of diagnosis, 15 to 20 percent of patients have growing tumors that have spread to the lungs or other bones.

The exact cause of osteosarcoma is unknown, and it cannot be prevented because it is a random mutation or change in the cells inside the bones. The only known environmental risk factor is exposure to radiation, as in previous radiation therapy for some other type of cancer.

About 3 to 4 percent of children with osteosarcoma carry mutations in certain genes that increase their risk for osteosarcoma. Diseases with mutations which increase the risk for osteosarcoma include:

  • Hereditary retinoblastoma. This is a form of eye cancer in children.
  • Li-Fraumeni syndrome. Children with this inherited condition are at risk for a range of cancers. The most common include sarcoma (osteosarcoma and soft tissue sarcoma), breast cancer, leukemia, brain tumor and adrenocortical carcinoma.
  • Werner syndrome. This rare inherited condition causes premature aging as well as increased risk for a range of cancers. The most common include thyroid cancer, melanoma, sarcoma (osteosarcoma and soft tissue sarcoma) and leukemia.
  • Rothmund-Thomson syndrome. This is a rare condition with symptoms including a characteristic facial rash, bone defects and a higher risk to develop osteosarcoma in childhood and skin cancer later in life.

What are symptoms of osteosarcoma?

Symptoms of osteosarcoma may appear weeks or months before it is diagnosed.

Symptoms include:

  • Pain in the affected bone that often increases with activity
  • Swelling that appears in the affected area, often a few weeks after pain begins
  • A lump or mass you can feel depending on the location
  • Possible break of the affected bone, although this is rare

How is osteosarcoma diagnosed?

How is osteosarcoma diagnosed?

Imaging procedures are the first step in diagnosing osteosarcoma. These may include:

  • X-ray. A plain radiograph of the affected area is generally the first diagnostic test. X-ray uses radiation to show bone and soft tissue and usually shows the tumor in the bone.
  • Magnetic resonance imaging (MRI). Using a magnetic field instead of radiation, a MRI scan provides the most detailed images of the tumors in the bone.
  • Computed tomography (CT) scan. CT scans of the chest can create detailed cross-sectional or even three-dimensional images to determine whether the osteosarcoma has spread to the lungs.
  • Radionuclide bone scanning with technetium. This is the preferred method for evaluating the entire skeleton for the presence of osteosarcoma

If imaging locates a tumor, a surgeon will take a biopsy (tissue sample) of the tumor. A pathologist (a physician who examines tissues) will then examine the cells under a microscope for signs of cancer. Once the pathologist confirms a diagnosis of osteosarcoma, an oncologist (cancer doctor) will evaluate all of the results to stage the tumor. Staging means assessing if the osteosarcoma has spread to the lungs or other bones.

Treatments for osteosarcoma

Treatments for osteosarcoma

Doctors at Riley at IU Health treat osteosarcoma with a combination of the following:

  • Chemotherapy. Chemotherapy medicines are given intravenously to shrink the tumor before surgically removing it.
  • Surgery. After initial chemotherapy the tumor may be removed depending on the location and advancement of osteosarcoma.
  • Radiation therapy. In some cases, radiation therapy is used to treat osteosarcoma. High-energy radiation is directed on the tumor to kill cancer cells.

Key Points To Remember

Key Points To Remember

  • Osteosarcoma is the most common bone cancer, or tumor, in children and adolescents and the third most common childhood cancer.
  • Osteosarcoma occurs more frequently in males than in females.
  • Symptoms of osteosarcoma may appear weeks or months before it is diagnosed.
  • Most osteosarcomas are found at an early stage before they have spread to other parts of the body.
  • Osteosarcoma is treated with a combination of chemotherapy and surgery and, in some cases, radiation therapy.

Support Services & Resources

Support Services & Resources

Visit these websites to learn more about osteosarcoma, its symptoms and treatments.

Riley at IU Health offers a broad range of supportive services to make life better for families who choose us for their children's care.

Learn More About Riley Support Services

Children’s Oncology Group

Find reliable information about all phases of childhood osteosarcoma, including diagnosis, treatment and follow-up care.

Osteosarcoma Research

Osteosarcoma Research

Riley at IU Health is a member of the Children's Oncology Group, which supports pediatric cancer research.

Locations

Locations

Locations

In addition to our primary hospital location at the Academic Health Center in Indianapolis, IN, we have convenient locations to better serve our communities throughout the state.

See all facilities →

Departments Treating This Condition

Departments Treating This Condition

  • Cancer & Blood Disorders
  • Fertility Preservation Program
  • Precision Genomics Program

Related Stories

Related Stories

Blog Kenley Window Wonderwoman

Nine-year-old superhero has cape, will fly

12/12/21 Patient Stories

Kenley Mullis beats back cancer, and now she hopes to walk and run and play like a kid again.

Continue reading
Riley Children's Health Indiana University School of Medicine
Designated as Best Children's Hospitals by U.S. News & World Report, Ranked in 10 Specialties in 2020-21

©2023 Riley Hospital for Children at
Indiana University Health
Find adult services at iuhealth.org

Get Informed

  • About Riley Children's Health
  • Family Support Services
  • Health Professionals
  • Medical Education
  • Newsroom
  • Riley Connections Blog
  • Careers
  • Legal Notices

I Want To…

  • Schedule an Appointment
  • Refer a Patient
  • Plan My Visit
  • Pay a Bill
  • Make a Donation
  • Volunteer
  • Find a Career

General Information

317.944.5000

Connect with Riley at IU Health

  • Facebook
  • Twitter
  • YouTube
  • LinkedIn
  • Instagram
  • RSS
Designated as Best Children's Hospitals by U.S. News & World Report, Ranked in 10 Specialties in 2020-21

©2023 Riley Hospital for Children at
Indiana University Health
Find adult services at iuhealth.org


Non-discrimination Notice

  • English
  • Español
  • Français
  • Burmese
  • Pennsilfaanisch Deitsch
  • 中文
  • Nederlands
  • Deutsch
  • Hakha
  • 日本語
  • Karen
  • 한국어
  • Русский
  • Tagalog
  • Tiếng Việt
  • العربية
  • हिंदी
  • ਪੰਜਾਬੀ
Back to top of the page