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Riley Children's Health

Precision Genomics Program

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The Precision Genomics Program at Riley Children’s Health helps children with all types of relapsed or aggressive cancer receive personalized treatment.

Our innovative approach to care can help reveal new treatment options that may be effective when other treatment options no longer work.

The precision genomics team uses genetic testing to identify DNA, RNA and proteins in cancer cells that can be precisely targeted with different treatments. Based on test results, the team recommends treatment options specific to your child’s needs. These targeted therapies may also have fewer side effects than previous treatments, helping your child have a better quality of life.

The Precision Genomics Program is the only program in Indiana to offer this comprehensive, personalized medicine service. We provide each step of care, from a biopsy of cancer cells to testing to evaluation and treatment.

Our multidisciplinary team includes a pediatric physician, nurse coordinator, pharmacist, molecular geneticist and social worker. The team works closely with other doctors, scientists and pediatric bioethicists at Riley Children’s.

What Your Family Can Expect

What Your Family Can Expect

Pediatric oncologists may refer you to the Precision Genomics Program if your child could benefit from our services. After we review the patient’s health information, we will quickly send tumor cells that were previously biopsied (surgically removed) for specialized testing.

While we wait for the test results, we will meet with patients and caregivers to share more about the program and what we look for in tumor cells. We will help you understand what to expect as you move forward with the next step in cancer treatment and will take the time to get to know your family.

After we receive the test results, we will work with your child’s oncologist and other specialists at Riley Children’s to explore treatment options best suited to your child’s particular form of cancer. We share these recommendations with your family, helping you understand your options so you can make informed decisions about your child’s care. You will then work with your child’s oncologist to move forward with the new treatments you choose.

When we make recommendations for your child’s care, we strive to consider your family’s preferences about how and where your child receives treatment.

Conditions & Services

Conditions Treated

Our pediatric specialists provide patient- and family-centered care for most related conditions. The links below provide more specific information about some, but not all, of the conditions that we treat.

  • Childhood Brain & Spinal Cord Tumors
  • Germ Cell Tumors
  • Leukemia
  • Liver Tumors
  • Lymphoma
  • Neuroblastoma
  • Osteosarcoma
  • Pediatric Ewing Sarcoma
  • Retinoblastoma
  • Rhabdomyosarcoma
  • Wilms Tumor

Doctors and Locations

Doctors

Doctors with the Precision Genomics Program offer personalized cancer treatment for children.

Locations

Locations

In addition to our primary hospital location at the Academic Health Center in Indianapolis, IN, we have convenient locations to better serve our communities throughout the state.

See all facilities →

Program Forms & Resources

Program Forms & Resources

The Precision Genomics Program at Riley at IU Health provides the following forms for parents, healthcare providers and personnel.

Forms

  • Patient Referral for Precision Genomics Program 188.592 KB

    Patient Referral for Precision Genomics Program

Related Programs & Departments

Related Programs & Departments

We provide multispecialty care for a number of conditions. Below are links to our related programs & departments.

  • Pediatric Cancer & Blood Disorders
  • Fertility Preservation Program
  • Medical & Molecular Genetics

Health Professionals

For Health Professionals

Learn more about the Precision Genomics Program. To refer a patient to the Precision Genomics Program, please call 317.944.2143. Families may also self-refer patients.

Research

The Precision Genomics Program is a fully integrated clinical research program helping children receive advanced, evidence-based care. Our providers are involved in research projects, including long-term studies of the benefits of precision genomics, new ways to treat relapsed cancer and techniques for identifying aggressive cancer. Research efforts, combined with fellowship training of pediatric oncologists, allow us to shape the future of pediatric cancer care.

Riley Children'sCenter for Cancer & Blood Diseases is affiliated with the IU Health Melvin and Bren Simon Cancer Center, the state’s only National Cancer Institute-designated cancer center for clinical care. Riley Children’s Health at IU Health is a Children’s Oncology Group Phase I Consortium member. Patients can access the latest clinical trials and leading-edge medications, all while under the care of highly skilled physicians and staff.

  • We offer cutting-edge clinical trials, giving qualified patients access to innovative investigational therapies.
  • We provide the only multidisciplinary center in Indiana offering genetic sequencing at the time of cancer diagnosis, enabling physicians to identify molecular drivers of tumors and enroll patients immediately into a molecular-guided treatment program, leading to better outcomes.

Find Clinical Trials

Education

The precision genomics team at Riley Children’s Health helps train the next generation of pediatric oncologists. Pediatric oncology/hematology fellows at the IU School of Medicine learn about the latest advancements in personalized cancer treatment by spending part of their training with our team.

Education Resources:
  • Fellows
Riley Children's Health Indiana University School of Medicine
Designated as Best Children's Hospitals by U.S. News & World Report, Ranked in 10 Specialties in 2023-24

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Indiana University Health
Find adult services at iuhealth.org

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Designated as Best Children's Hospitals by U.S. News & World Report, Ranked in 10 Specialties in 2023-24

©2025 Riley Hospital for Children at
Indiana University Health
Find adult services at iuhealth.org


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