Better health for children happens only through a relentless commitment to research and innovation—one that is shared by physicians, researchers and also by families affected by a child’s health condition. As a nationally-ranked pediatric research hospital Riley Children's Health is one of the busiest locations in the United States for funded pediatric research.
Through participation in our clinical trials, families have a wide range of opportunities to become part of a process that helps doctors and scientists find treatments, tests and services that improve what is already available for all children. Clinical trials also study ways to detect, diagnose and prevent disease.
Our devotion to research stems from the fact that we have expert subspecialists who care for children with life’s most serious injuries and conditions, or rare, life-threatening diseases. Children in Indiana, parts of the Midwest and worldwide are referred to Riley Children's Health for diagnosis and treatment because our physicians work with these problems on a daily basis and provide a level of care that is not available in all healthcare systems.
We have achieved this level of excellence in part by having physicians, scientists and healthcare providers who are steeped in patient care, research and innovation in nearly every area of pediatric health. As witnesses to the effects certain diseases and treatments have on families, we are highly motivated to find new treatments that cause fewer hardships and better outcomes for children.
Find a clinical trial near you
View all active IU Health and Riley Children's Health clinical trials
Frequently Asked Questions
Frequently Asked Questions
What is a clinical trial?
Most clinical trials can be categorized in one of two ways: Observational studies and Interventional studies. Clinical trials—especially interventional studies—are often the result of discoveries that start in a laboratory with basic science. In clinical trials, researchers can conduct further study on new procedures, medications and devices after an independent institutional review board (IRB) deems them ethical, worthwhile and safe to be tested with humans. Clinical trials may be conducted in phases at multiple sites across the country to get a sample of patients that is large enough to draw conclusions by scientific standards.
What is the value of pediatric research?
The majority of children in the United States are healthy. Those who are not healthy have thousands of complex conditions that require specialized care. Unhealthy adults far outnumber children with health issues. Biomedical companies tend to focus their research investments on adult diseases because it is a larger market with fewer diseases. This makes pediatric healthcare research especially important among other institutions and academic health centers like Riley Children's, Indiana University School of Medicine, Indiana University School of Nursing and Indiana University School of Health & Rehabilitation Sciences.
Clinical trials help doctors learn how to treat many childhood diseases that either have poor treatment options or have no successful treatments at all. Pediatric research allows us to learn how existing drugs may be used in other ways and how to modify adult treatments for children. Physicians and scientists also conduct research to find the right strategies to keep children healthy in specific circumstances. Some clinical trials are not focused on treatments, but instead explore new ways to detect, diagnose and prevent disease.
What are Observational studies?
These studies gather information through surveys, interviews, examinations and direct observation of patient behaviors, but they do not attempt to change anything.
What are Interventional studies?
Interventional studies are designed to try new treatments, services or tests to verify their safety and see how patients respond.
Why would I want to enroll my child in research?
Parents are motivated to consider clinical trials for their children by many factors. Some parents appreciate the extra level of interest and monitoring their child receives in a clinical trial, especially if their child has a serious disease. Participation in research often helps children and families use their experience to do something positive for other people. For some families, the promise of a better future for other children adds meaning to the hardships they face with an illness. Children enrolled in clinical trials are first to benefit from new therapies, and they draw strength by connecting with other families who share the same problems.
Who pays for pediatric research?
The National Institutes of Health, which is funded by U.S. citizens through taxes, is one of the biggest sources of pediatric healthcare research. Researchers at academic health centers like the one formed by Riley Children's Health and Indiana University apply for grants to support their research ideas and clinical trials. Money to support pediatric research may also come from pharmaceutical and biomedical companies, foundations, volunteer organizations and not-for-profit health organizations.
Can anyone participate in a clinical trial?
Not everyone who applies for a clinical trial is accepted. Each study has a set of guidelines that must be met to make sure children can participate safely. Parents and/or guardians must give permission for children to participate and children of a certain age must give their agreement, too.
How can I decide whether to enroll my child in research if the opportunity is offered to me?
One of the best ways to make your decision is to gather information. Start by having a conversation with the physicians who may have suggested the clinical trial to you. Include a trusted friend or family member in the conversation as another set of ears to help you gain perspective on what you hear. Most clinical trials have risks and benefits. Ask researchers to share both. Find out what your responsibilities are, how long the study will last and what researchers expect to gain from the trial. Ask how it will affect your child’s existing medical care and what procedures, tests or treatments will be required. Determine who will pay for costs related to the clinical trial and whether your insurance will cover any cost that is not covered by the clinical trial.
How can I volunteer for a clinical trial?
Finding the right clinical trial for your child may be the first step to participation. One of the best ways to locate clinical trials led by Riley at IU Health physicians is through the Indiana Clinical and Translational Sciences Institute (ICTSI)—a statewide collaboration between Indiana University, Purdue University and the University of Notre Dame. Patients who are interested in participating in health-related research can also register to be matched with compatible research at INresearch.org.
The ICTSI website contains a complete list of clinical trials available in Indiana and can be sorted by the type of research and the audience. Most pediatric studies listed there are conducted at the Children’s Clinical Research Center on the campus of Riley Children's Health.
Parents and caregivers can also find clinical trials through ClinicalTrials.gov, published by the U.S. National Institutes of Health. This website lists national and international research, and you can search for pediatric clinical trials conducted in Indiana by limiting your search terms. Both sites contain useful information about how clinical trials work.
