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Riley Children's Health

Clinical Pathways

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Riley Children’s Health aims to standardize care and improve patient outcomes through clinical pathways. With our collaborative structure, we offer peer-reviewed, evidence-based best practices for various conditions.

Learn more from any of the following treatment guidelines

Learn more from any of the following treatment guidelines

Agitation and Aggression Treatment

This best practice algorithm provides guidance on de-escalation techniques and medical management for pediatric patients displaying agitation and aggressive behavior. Medication suggestions and appropriate weight-based dosing can be found on the algorithm to ensure safe and appropriate care of pediatric behavioral health patients.

Agitation and Aggression Treatment Plan

Allergic Reaction and Anaphylaxis

This best practice algorithm provides guidance on identification of severe allergic reaction or anaphylaxis in pediatric patients and includes recommendations on appropriate medication selection, dosages, and patient disposition based on symptoms.

Allergic Reaction and Anaphylaxis Guidelines

Anxiolysis

This best practice algorithm provides guidance for the use of pharmacologic and non-pharmacologic measures to help decrease pediatric patient anxiety in the Emergency department or office setting.

Anxiolysis Guidelines

Bronchiolitis

This best practice algorithm provides evidence-based recommendations on the diagnosis, testing, general treatment, and patient disposition for pediatric bronchiolitis.

Bronchiolitis Guidelines

Burn Care

This best practice algorithm provides guidance for appropriate pain control and treatment of pediatric burns. Recommendations for when to consult with the Riley Children’s Health Burn Center are also included.

Burn Treatment Protocol​

Cervical Spine Injury

This best practice algorithm provides guidance on diagnosis, medical management, and radiologic recommendations for pediatric patients with cervical spine injury.

Spinal Cord Injury Guidelines

Community Acquired Pneumonia

This best practice algorithm provides guidance for diagnosis and treatment of community acquired pneumonia in the pediatric population.

Community Acquired Pneumonia Treatment Guidelines

Croup

This best practice algorithm provides evidence-based recommendations on diagnosis, medical management, and safe disposition for pediatric croup.

Croup Treatment Guidelines

Diabetic Ketoacidosis

This best practice algorithm provides recommendations for the diagnosis and treatment of pediatric diabetic ketoacidosis. Recommendations on prevention, diagnosis, and treatment of cerebral edema are also included.

Diabetic Ketoacidosis Guidelines​

Golden Hour

This best practice algorithm identifies key pediatric disease states that require prompt evaluation and treatment to assist triage decision making in the ED and office setting.

Golden Hour Trauma Guidelies​

Febrile Neutropenia

This best practice algorithm provides standardized recommendations for timely, appropriate antimicrobial selection for a pediatric patient with febrile neutropenia.

Febrile Neutropenia Guidelines

Fever in Well Appearing Infants Less than 60 Days Old

This best practice algorithm provides a streamlined approach for the treatment of well-appearing febrile infants < 60 days old, based on latest AAP guidelines.

Febrile Infant Guidelines​

Headache

This best practice algorithm provides guidance for the management of pediatric headaches.

Headache Guidelines

Measles Testing, Isolation, and Post-Exposure Prophylaxis

This best practice algorithm provides guidance on measles testing and diagnosis, isolation, and post-exposure prophylaxis recommendations.

Measles Testing, Isolation, and Post-Exposure Prophylaxis Guidelines

Rapid Sequence Intubation

This best practice algorithm provides guidance for rapid sequence intubation, including guidance on endotracheal tube sizing, blade and medication selection, and medication dosing.

Rapid Sequence Intubation Guidelines

Respiratory Viral Testing

This best practice algorithm provides standardized evidence-based recommendations guiding providers caring for pediatric patients to minimize unnecessary viral testing for pediatric patients.

Respiratory Viral Testing Guidelines

Sepsis

This best practice algorithm supports recognition and implementation of appropriate, timely management of pediatric sepsis, including fluid resuscitation, laboratory orders, and weight-based antimicrobial selection.

Sepsis Protocol

Sickle Cell Disease: Pain and Fever Treatment

This best practice algorithm provides standardized evidence-based recommendations for pediatric patients presenting with fever or pain to ensure rapid assessment and treatment.

Sickle Cell Disease: Pain and Fever Treatment Guidelines

Status Epilepticus

This best practice algorithm provides standardized evidence-based recommendations for pediatric patients presenting with seizure or status epilepticus to ensure rapid, safe assessment and treatment.

Status Epilepticus Guidelines

Stroke

This best practice algorithm provides standardized evidence-based recommendations to guide recognition and treatment of pediatric stroke management.

Stroke Guidelines

Traumatic Brain Injury

This best practice algorithm guides treatment and management for children presenting with traumatic brain injuries by promoting the use of the evidence-based PECARN head rules.

Traumatic Brain Injury Guidelines

Urinary Tract Infection

This best practice algorithm guides in diagnosis and treatment of pediatric urinary tract infection, including guidance on antibiotic selection, dosing, and treatment duration.

UTI Guidelines​

Trauma and Acute Care Support Guide

Trauma and Acute Care Support Guide

Discover advanced acute care and trauma solutions for your patients.

The information contained in our guidelines is designed for general use. Each clinician should use their judgment to meet the needs of each individual patient. View our full medical content notice.

To transfer a patient, call

877.247.1177
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Designated as Best Children's Hospitals by U.S. News & World Report, Ranked in 10 Specialties in 2023-24

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Indiana University Health
Find adult services at iuhealth.org

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Designated as Best Children's Hospitals by U.S. News & World Report, Ranked in 10 Specialties in 2023-24

©2025 Riley Hospital for Children at
Indiana University Health
Find adult services at iuhealth.org


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